Cancer Treatment
Dealing with cancer is one the greatest burdeons we can bear. The feeling of disempowerment by the disease and even the health system can be overwhelming. Seeking a cure has become an increasingly confusing task.
Conventional cancer treatments seem to have more health consequences than the cancer itself, and many alternative cancer treatments seem to be just quackery!
Choosing a cancer treatment to suit your needs is a difficult personal path to tread indeed.
We have assembled some of the cancer treatments here for you to consider, but again we do not condone them, simply offer them for your consideration.
| MedWorm: Cancer Therapy Updated : Fri, 27 Jan 2012 02:56:53 +0100 Combination of TRAIL and JAK-2 Downregulation: Novel Therapeutic Strategy Against Pancreatic Cancer Conclusions: Inhibition of JAK-2 pathway sensitizes pancreatic cancer cells to TRAIL induced apoptosis and cell death. Combination of JAK-2 silencing and TRAIL has immense potential to emerge as novel therapeutic strategy against pancreatic cancer. (Source: Journal of Surgical Research) Author : Journal of Surgical Research Publ.Date : Sat, 14 Jan 2012 22:29:04 +0100 Controlling cancer through the autotaxin-lysophosphatidic acid receptor axis. Authors: Gotoh M, Fujiwara Y, Yue J, Liu J, Lee S, Fells J, Uchiyama A, Murakami-Murofushi K, Kennel S, Wall J, Patil R, Gupte R, Balazs L, Miller DD, Tigyi GJ Abstract LPA (lysophosphatidic acid, 1-acyl-2-hydroxy-sn-glycero-3-phosphate), is a growth factor-like lipid mediator that regulates many cellular functions, many of which are unique to malignantly transformed cells. The simple chemical structure of LPA and its profound effects in cancer cells has attracted the attention of the cancer therapeutics field and drives the development of therapeutics based on the LPA scaffold. In biological fluids, LPA is generated by ATX (autotaxin), a lysophospholipase D that cleaves the choline/serine headgroup from lysophosphatidylcholine and lysophosphatidylserine to generate LPA. In the pre... MedWorm Sponsor Message: Find the best January Sales in the UK. Author : Biochemical Society Transactions Publ.Date : Sun, 22 Jan 2012 22:31:40 +0100 Targeting MicroRNA-196a by a Plasmid-based Antagomir for Pancreatic Cancer Therapy (Source: Journal of Surgical Research) Author : Journal of Surgical Research Publ.Date : Sat, 14 Jan 2012 22:30:09 +0100 Formulating dual-function nanoparticles for photodynamic and photothermal cancer therapy Carbon nanotube–chitosan–phycocyanin complex displays photoinduced cytoxicity (Source: Nanotechweb.org journal highlights) Author : Nanotechweb.org journal highlights Publ.Date : Thu, 12 Jan 2012 14:35:13 +0100 Contrast CT, PET/CT assess cancer therapy for melanoma Dynamic contrast-enhanced CT and FDG-PET/CT can provide additional information (more) (Source: AuntMinnie.com Headlines) Author : AuntMinnie.com Headlines Publ.Date : Thu, 12 Jan 2012 19:43:00 +0100 Androgen Stimulation of TORC2 [Cell Biology] This study reveals a pathway linking AR to a selective activation of TORC2, the subsequent activation of AKT, and phosphorylation of a discrete set of AKT substrates that regulate cellular proliferation and survival. These findings establish that TORC2 can function as a central regulator of growth in response to signals that are distinct from those regulating TORC1, and support efforts to target TORC2 for cancer therapy. (Source: Journal of Biological Chemistry) Author : Journal of Biological Chemistry Publ.Date : Fri, 13 Jan 2012 05:00:00 +0100 Estrogen receptor β (ERβ) is a novel prognostic marker of recurrence survival in non-muscle-invasive bladder cancer potentially by inhibiting cadherin switch Conclusion ERβ is a prognostic marker of recurrence-free rate in non-muscle-invasive bladder cancer, potentially through suppressing cadherin switch, and may act as a potential target for bladder cancer therapy. Content Type Journal ArticleCategory Original ArticlePages 1-7DOI 10.1007/s00345-011-0819-4Authors Bangmin Han, Department of Urology, School of Medicine, The First Peopleâs Hospital Affiliated to Shanghai Jiao Tong University, Shanghai, Peopleâs Republic of ChinaDi Cui, Department of Urology, School of Medicine, The First Peopleâs Hospital Affiliated to Shanghai Jiao Tong University, Shanghai, Peopleâs Republic of ChinaYifeng Jing, Department of Urology, School of Medicine, The First Peopleâs Hospital Affiliated to Shanghai Jiao Tong University, S... MedWorm Sponsor Message: Find the best January Sales in the UK. Author : World Journal of Urology Publ.Date : Wed, 11 Jan 2012 17:52:25 +0100 [Podcast] Science Podcast The show includes a Sun-grazing comet, protecting against the shiga toxin, the risks of experimental cancer therapies, and more. (Source: Science: Current Issue) Author : Science: Current Issue Publ.Date : Sat, 21 Jan 2012 17:26:17 +0100 Construct validity of the EORTC quality of life questionnaire information module Conclusion The suggested construct of the INFO25 with a total score (general factor) in addition to the subscales is valid. Content Type Journal ArticlePages 1-7DOI 10.1007/s11136-012-0114-xAuthors Susanne Singer, Department of Medical Psychology and Medical Sociology, University of Leipzig, Philipp-Rosenthal-Str. 55, 04103 Leipzig, GermanyPhilipp M. Engelberg, Department of Methods and Psychodiagnostics, University of Wuppertal, Wuppertal, GermanyGregor WeiÃflog, Department of Medical Psychology and Medical Sociology, University of Leipzig, Philipp-Rosenthal-Str. 55, 04103 Leipzig, GermanySusanne Kuhnt, Department of Medical Psychology and Medical Sociology, University of Leipzig, Philipp-Rosenthal-Str. 55, 04103 Leipzig, GermanyJochen Ernst, Department of Medical Psy... Author : Quality of Life Research Publ.Date : Tue, 17 Jan 2012 07:08:41 +0100 The interplay of HER2/HER3/PI3K and EGFR/HER2/PLCâγ1 signalling in breast cancer cell migration and dissemination AbstractHER2 signalling by heterodimerization with EGFR and HER3 in breast cancer is associated with worst outcome of the afflicted patients, which is not only attributed to the aggressiveness of such tumours, but also to therapy resistance. In the present study we thus investigated the role of EGFR, HER2, and HER3 lateral signalling in cell migration by applying the MDAâMBâ468âHER2 (MDAâHER2) breast cancer cell line representing a valid model system. Knockdown of HER3 expression by siRNA resulted in decreased pAKT levels, abrogated EGFâmediated PLCâ?1 activation, and a diminished EGFâinduced migratory activity depicting the interplay of EGFR/HER2/PLCâ?1 and HER2/HER3/PI3K signalling in mediating the migration of EGFR/HER2/HER3 expressing breast cancer cells. Since therapy ... Author : The Journal of Pathology Publ.Date : Thu, 19 Jan 2012 05:00:00 +0100 A poly(glycerol-sebacate-(5-fluorouracil-1-acetic acid)) polymer with potential use for cancer therapy In this study, 5-fluorouracil-1-acetic acid was chemically conjugated with poly(glycerol-sebacate) (PGS) to form a unitary polymer poly(glycerol-sebacate- (5-fluorouracil-1-acetic acid)) (PGS-5-FU-CH2COOH). The structure, the in vitro antitumor activity of 5-FU-CH2COOH, the in vitro degradation, the drug release, and antitumor activity as well as the in vivo degradation and tissue biocompatibility of PGS-5-FU-CH2COOH were investigated. The 5-FU-CH2COOH inhibited HeLa (human cervical cancer cell line) and SGC-7901 (human gastric adenocarcinoma cell line) tumor cells with a half maximal inhibitory concentration (IC50) of 0.196 and 0.267 μM, respectively, after a 3-day incubation. The in vitro drug release profiles of PGS-5-FU-CH2COOH exhibited a biphasic release with an initial exponentia... MedWorm Sponsor Message: Find the best January Sales in the UK. Author : Journal of Bioactive and Compatible Polymers Publ.Date : Wed, 18 Jan 2012 05:00:00 +0100 Expression and glucocorticoid-regulation of "Bam", a novel BH3-only transcript in acute lymphoblastic leukemia. Expression and glucocorticoid-regulation of "Bam", a novel BH3-only transcript in acute lymphoblastic leukemia. Mol Biol Rep. 2012 Jan 12; Authors: Mansha M, Wasim M, Kofler A, Ploner C Abstract Apoptosis is a morphologically defined form of cell death that plays a major role in cell physiology, pathology and cancer therapy. The Bcl-2 family of pro- and anti-apoptotic molecules is a key regulator of this phenomenon, with the sub-family of BH3-only molecules serving as activators and/or facilitators. Apoptosis induced by glucocorticoids (GC) is a central component in the therapy of acute lymphoblastic leukemia (ALL), and defining its molecular basis and that of GC resistance is crucial for therapeutic improvements. We recently identified a novel transcript from the BCL2L11/B... Author : Molecular Biology Reports Publ.Date : Thu, 12 Jan 2012 05:00:00 +0100 Histone H3 phosphorylation, immediate-early gene expression, and the nucleosomal response: a historical perspective (1) (1) This article is part of Special Issue entitled Asilomar Chromatin and has undergone the Journal's usual peer review process. This article is part of Special Issue entitled Asilomar Chromatin and has undergone the Journal's usual peer review process. Biochem Cell Biol. 2012 Jan 17; Authors: Healy S, Khan P, He S, Davie JR Abstract Histone H3 is modified at serines 10 and 28 in interphase cells following activation of the RAS-MAPK or p38-MAPK pathways by growth factors or stress. These modifications are involved in the regulation of immediate-early genes, including Jun and Fos, whose increased expression is a trademark of various cancers. This review outlines the series of discoveries that led to the characterization of these modifications, the kinase, MSK1/2, which is activated by both MAPK pathways and directs phosphorylation of H3, and the mechanistic function of these modifications in transcrip... Author : Biochemistry and Cell Biology Publ.Date : Tue, 17 Jan 2012 05:00:00 +0100 Georgetown University Medical Center licenses 'theranostic' for development (Georgetown University Medical Center) Georgetown University Medical Center has licensed worldwide rights of a potential novel cancer therapy and diagnostic, or "theranostic," to BioMetrx, LLC. The agent was invented by two Georgetown researchers. (Source: EurekAlert! - Medicine and Health) Author : EurekAlert! - Medicine and Health Publ.Date : Tue, 24 Jan 2012 05:00:00 +0100 Progress in Cancer Therapy Cancer Biotherapy & Radiopharmaceuticals , Vol. 0, No. 0. (Source: Cancer Biotherapy and Radiopharmaceuticals) Author : Cancer Biotherapy and Radiopharmaceuticals Publ.Date : Tue, 10 Jan 2012 20:26:29 +0100 Anticancer Properties of Pomolic Acid-Induced AMP-Activated Protein Kinase Activation in MCF7 Human Breast Cancer Cells. In this study, we investigated PA activated AMPK, and this activity was related to proliferation and apoptosis in MCF7 breast cancer cells. PA inhibited cell proliferation and induced sub-G(1) arrest, elevating the mRNA levels of the apoptotic genes p53 and p21. PA activated caspase-3, -9, and poly(ADP-ribose) polymerase, and this effect was inhibited by z-VAD-fmk. AMPK activation was increased by treating cells with PA, inactivated by treating cells with a compound C, and co-treatment consisting of PA and aminoimidazole carboxamide ribonucleotide (AICAR) synergistically activated AMPK. These anti-cancer potentials of PA were accompanied by effects on de novo fatty acid synthesis as shown by the decreased expression of fatty acid synthase, and decreased acetyl-CoA carboxylase activation an... MedWorm Sponsor Message: Find the best January Sales in the UK. Author : Biological and Pharmaceutical Bulletin Publ.Date : Fri, 13 Jan 2012 09:48:02 +0100 Apoptosis and survival Manjul TiwariIndian Journal of Human Genetics 2011 17(3):120-125The term apoptosis first appeared in the biomedical literature in 1972, to delineate a structurally distinctive mode of cell death responsible for cell loss within living tissues. The cardinal morphological features are cell shrinkage, accompanied by transient but violent bubbling and blebbing from the surface, and culminating in separation of the cell into a cluster of membrane-bounded bodies. Changes in several cell surface molecules also ensure that, in tissues, apoptotic cells are immediately recognised and phagocytosed by their neighbours. However, it is important to note that apoptosis is only one form of cell death and the particular death pathway that is the most important determinant for cancer therapy is not necessar... Author : Indian Journal of Human Genetics Publ.Date : Fri, 20 Jan 2012 05:00:00 +0100 The rheological properties of different GNPs Conclusions: The torque%, viscosity (cp) and SS (dyne/cm2) of all GNP sizes decreased with increasing the temperature and with decreasing the GNP size (for each fixed temperature value). For each shear rate value, the viscosity of all GNPs decreased with decreasing the GNP size. This study demonstrates that the physical, dimensional and morphological changes of GNPs have effective influence on their rheological properties. To understand and categorize the role of GNPs in drug delivery and cancer therapy, GNPs of varying size, number of particles, shape and surface should be taken into consideration. Moreover, further additional in vivo studies after administration of GNPs in rats should be performed to support this hypothesis. (Source: Lipids in Health and Disease) Author : Lipids in Health and Disease Publ.Date : Tue, 24 Jan 2012 05:00:00 +0100 BMPâ2 inhibits tumor growth of human renal cell carcinoma and induces bone formation This study investigates the effect of BMPâ2 on human renal cell carcinoma using ACHN and Cakiâ2 cell lines. Three types of BMP receptors were found to be expressed in ACHN and Cakiâ2 cells. In vitro, BMPâ2 was found to inhibit the growth of ACHN and Cakiâ2 cells. The antiproliferative effect seems to be due to cell cycle arrest in the G1 phase, which was revealed by flow cytometry analysis. Using RTâPCR analysis, we demonstrated BMPâ2 upâregulated osteogenic markers Runxâ2 and Collagen Type I gene expression in ACHN and Cakiâ2 cells. Treatment of ACHN and Cakiâ2 cells with BMPâ2 induced a rapid phosphorylation of Smad1/5/8. In vivo, all animals receiving low number of ACHN (1Ã104) and Cakiâ2 (5Ã104) cells treated with 30 μg BMPâ2 per animal showed limited tum... Author : International Journal of Cancer Publ.Date : Tue, 24 Jan 2012 05:00:00 +0100 Regulation of HGF-mediated cell proliferation and invasion through NF-κB, JunB, and MMP-9 cascades in stomach cancer cells In conclusion, these results may contribute to the JunB-associated malignant phenotype of gastric cancers by regulating MMP-9, and serve as a novel therapeutic target for stomach cancer therapy in the future. Content Type Journal ArticleCategory Research PaperPages 1-10DOI 10.1007/s10585-011-9449-xAuthors Kyung Hee Lee, Department of Hematology-Oncology, College of Medicine, Yeungnam University, Daegu, Republic of KoreaJae-Ryong Kim, Department of Biochemistry and Molecular Biology, College of Medicine, Yeungnam University, 317-1 Daemyung-Dong, Daegu, 705-717 Republic of Korea Journal Clinical and Experimental MetastasisOnline ISSN 1573-7276Print ISSN 0262-0898 (Source: Clinical and Experimental Metastasis) Author : Clinical and Experimental Metastasis Publ.Date : Wed, 18 Jan 2012 06:48:28 +0100 Increased Website Traffic |